Extended DMT Trips

The development of a prolonged N,N-Dimethyltryptamine (DMT) experience would be an important step towards allowing for a closer study of its phenomenology and neurobiological effects, and would make it possible to control the length, intensity, and dynamics of the DMT experience, with the potential for real-time adjustment. This could make extended DMT a valuable tool in conjunction with therapy, to tailor the psychedelic effects to the individual needs of each patient and their clinical condition, as well as for consciousness research, whereby the intensity of the DMT experience can be adjusted according to specific hypotheses and research questions. Continuous infusions of DMT were safely administered for up to 90 min and the infusion rates were reported to be determined via a previous pilot study with six subjects. However, this report lacked information on how strong and sustained these effects were over time. Another approach was proposed, aiming to generate stable subjective effects via a continuous infusion of the drug but unfortunately, this protocol has not been implemented in human participants. Overall, no pharmacokinetically informed protocols of IV DMT have been tested in humans to date.

The present study developed the first systematic protocol for the continuous IV infusion of DMT and tested its effectiveness in healthy volunteers. The main goal of the study was to provide first steps towards establishing infusion parameters for maintaining a steady state of DMT effects for a chosen length of time.

Psychological and physiological effects of extended DMT

The DMT experience shares similarities with the near-death experience and is frequently deemed profound, at times leading to lasting revisions of beliefs about the nature of reality and consciousness. DMT is therefore a powerful tool for the study of consciousness.

Dr. Chris Timmermann obtained his PhD (2020) working with Robin Carhart-Harris, and David Nutt, and led the DMT Research Group (2020-2024) at Imperial College London at the Centre for Psychedelic Research. He currently is the co-director of the UCL Centre for Consciousness Research where he investigates the impact of meditation and psychedelics in the mind and brain and is the founder and director for the ECOH Foundation for the Study of Human Consciousness.

https://www.youtube.com/embed/0I527fqNvV4



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